Atr Inhibitor Clinical Trial

These cancer cells become more reliant on their S and G2M checkpoints making this an attractive anti-cancer target. Find answers to these questions.

Cancer Specific Synthetic Lethality Between Atr And Chk1 Kinase Activities Sciencedirect

This phase I trial assessed the ATR inhibitor M6620 VX-970 as monotherapy once or twice weekly and combined with carboplatin carboplatin on day 1 and M6620 on days 2 and 9 in 21-day cycles.

Atr inhibitor clinical trial. All trials on the list are supported by NCI. PATIENTS AND METHODS This phase I trial assessed the ATR inhibitor M6620 VX-970 as monotherapy once or twice. The purpose of the proposed trial is to evaluate the safety and tolerability of BAY1895344 and to identify the maximum tolerated dose of BAY1895344 that could be safely given to cancer patients.

The ATRataxia-telangiectasia and Rad3 related protein inhibitor BAY1895344 is developed for the treatment of patients with advanced solid tumors and lymphomas. In the first stage of the ATARI trial a total of thirty patients with relapsed gynaecological cancers will be recruited into three cohorts. Download your free virtual clinical trials resource bundle.

How feasible are they. NCIs basic information about clinical trials explains the types and phases of trials and how they are carried out. PATRIOT is a phase I study of the ATR inhibitor AZD6738 as monotherapy and in combination with palliative radiotherapy.

ATARI is a multi-centre open-label multiple two-stage parallel cohorts phase II clinical trial for patients with relapsed gynaecological cancers with ARID1A-deficient loss and no loss The trial tests the ATR inhibitor drug AZD6738 and a PARP inhibitor drug olaparib to assess the response in groups of patients selected based on their cancer cell subtype and the presence of an abnormality in. Estimated Study Completion Date. The SWISNF chromatin-remodelling complex is.

How feasible are they. The clinical trials on this list are studying ATR Kinase Inhibitor AZD6738. Clinical trials look at new ways to prevent detect or treat disease.

Study Start Date. Secondary objectives included pharmacokinetics and antitumor activity. Estimated Primary Completion Date.

Estimated Primary Completion Date. The ATRataxia-telangiectasia and Rad3 related protein inhibitor BAY1895344 is developed for the treatment of patients with advanced solid tumors and lymphomas. Ten patients with ovarian clear cell or endometrial clear cell cancer and ARID1A loss will be allocated into cohort 1A and treated with single agent AZD6738.

Estimated Study Completion Date. Clinical trials are research studies that involve people. Primary objectives were safety tolerability and maximum tolerated dose.

Exploratory objectives included pharmacodynamics. Ad Are virtual clinical trials better. Estimated Primary Completion Date.

First ATR inhibitor to enter clinical trials Has demonstrated strong chemo- and radio-sensitising abilities in multiple cancer models both in-vitro and in-vivo Chemo-sensitising potential of this agent is more profound with Pt-based chemotherapy. Actual Study Start Date. A Phase I Study to Assess the Tolerability Safety and Biological Effects of ATR Inhibitor AZD6738 as a Single Agent and in Combination With Palliative Radiation Therapy in Patients With Solid Tumours.

Merck KGaAs ATR inhibitor cancer drug has been cleared for further clinical trials after it showed encouraging activity in a phase 1 study. Download your free virtual clinical trials resource bundle. Find answers to these questions.

An Open-label Phase 1b Study to Determine the Maximum Tolerated andor Recommended Phase 2 Dose of the ATR Inhibitor BAY 1895344 in Combination With PARP Inhibitor Niraparib in Patients With Recurrent Advanced Solid Tumors and Ovarian Cancer. PURPOSE Preclinical studies demonstrated that ATR inhibition can exploit synthetic lethality eg in cancer cells with impaired compensatory DNA damage responses through ATM loss as monotherapy and combined with DNA-damaging drugs such as carboplatin. Here we describe the protocol for this study which opened in 2014 and is currently recruiting and comprises dose escalation of both drug and radiotherapy and expansion cohorts.

Ad Are virtual clinical trials better. Therefore as ATRi enter Phase 1 clinical trials it is clear that there is a pressing need to identify clinically useful biomarkers of sensitivity 5. Targeting ATR is the focus of many oncology drug pipelines with a number of potent selective ATR inhibitors developed four M6620 M4344 AZD6738 and BAY1895344 are currently in clinical development.

The Novel ATR Inhibitor BAY 1895344 Is Efficacious as Monotherapy and Combined with DNA Damage-Inducing or Repair-Compromising Therapies in Preclinical Cancer Models Mol Cancer Ther. Combination ATR and PARP Inhibitor CAPRI Trial With AZD 6738 and Olaparib in Recurrent Ovarian Cancer. Actual Study Start Date.

The purpose of the proposed trial is to evaluate the safety and tolerability of BAY1895344 and to identify the maximum tolerated dose of BAY1895344 that could be safely given to cancer patients. Epub 2019 Oct 3.

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Progress Towards A Clinically Successful Atr Inhibitor For Cancer Therapy Sciencedirect